I'm not anywhere close to being an expert on professional QA and testing but I do work with it as part of managing a IT system at work. To be honest, we are not very mature when it comes to using an actual framework or methodology and our tool support is quite lacking too. This has been painfully obvious in course of us upgrading to the newest version of the IT system.
I'm afraid tool support has more or less been decided. Oracle Primavera has been used so for managing projects - and from my perspective - issues. Quality Center has been used so far functional testing of the new version of the IT system. Service Manager has been chosen as the new ticket system for support of the IT system. I'll be working in that landscape in the future, not really sure what tool will be used.
What I'm looking for is more in terms of a framework or methodology. We have in-house developments and vendor-developed enhancements that needs tracking and QA. We do automated testing, regression testing of our databases before releases and functional/user acceptance testing. Any ideas?